The basics

TB-500 for dogs: what UK owners should know

What TB-500 is, how it relates to thymosin beta-4, what the research covers and which dog peptide brands sell it.

By The Puptides Desk. Updated 2026-11-13.

TB-500 is the second most talked about dog peptide after BPC-157, and it is often sold alongside it.

What is TB-500?

A synthetic peptide related to thymosin beta-4, a protein found in many tissues. TB-500 is a trade name. Products sold under it are not always the same molecule, which makes comparing them harder.

What does the research cover?

Thymosin beta-4 has been studied in laboratory models of wound healing, the eye and the heart, with some early human work on the full protein. There are no large controlled trials in dogs.

A racing connection

TB-500 has a history in horse and greyhound racing, where it is a banned substance. It is also on the World Anti-Doping Agency prohibited list.

Is it legal in the UK?

It is not an authorised veterinary medicine. See Are dog peptides legal in the UK?

Which brands sell it?

Several of the brands in our rankings sell TB-500, alone or blended with BPC-157. Peps for Pups, the UK brand connected to this site, sells BPC-157 only.

TB-500 or BPC-157?

They are different compounds. See BPC-157 vs TB-500 for dogs.

Read next

The people who run Puptides are personally connected to Peps for Pups, one of the brands reviewed here. Every brand is scored on the same four published checks, and we link our sources so you can verify them.